Beilstein J. Org. Chem.2021,17, 1392–1439, doi:10.3762/bjoc.17.98
methodologies and the biological applications of double-headed nucleosides.
Keywords: acyclic double-headed nucleosides; bicyclicdouble-headednucleosides; furanosyl double-headed nucleosides; modified nucleosides; pyranosyl double-headed nucleosides; Introduction
Nucleosides are the constructional subunits
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Bicyclicdouble-headednucleosides
In this section we have included the double-headed nucleoside monomers, which have a locked nucleic acid type conformation and the additional nucleobase is attached at one of the carbon or nitrogen atoms constituting the bridge (Figure 1). All examples
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Graphical Abstract
Figure 1:
Double-headed nucleosides. B1 and B2 = nucleobases or heterocyclic/carbocyclic moieties; L = linker....